Nature Communications (Aug 2016)

Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

  • Violeta I. Gallardo-Montejano,
  • Geetu Saxena,
  • Christine M. Kusminski,
  • Chaofeng Yang,
  • John L. McAfee,
  • Lisa Hahner,
  • Kathleen Hoch,
  • William Dubinsky,
  • Vihang A. Narkar,
  • Perry E. Bickel

DOI
https://doi.org/10.1038/ncomms12723
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

Perilipin 5 has been implicated as a modulator of lipase activity and a scaffold linking lipid droplets to mitochondria. Here the authors show that PKA stimulates Peripilin 5 interaction with nuclear PGC-1a and SIRT1 to promote transcription of genes regulating mitochondrial biogenesis and respiration.