5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients

Kevin C. Johnson; E. Andres Houseman; Jessica E. King; Katharine M. von Herrmann; Camilo E. Fadul; Brock C. Christensen

doi:10.1038/ncomms13177

Nature Communications (Nov 2016)

5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients

Kevin C. Johnson,
E. Andres Houseman,
Jessica E. King,
Katharine M. von Herrmann,
Camilo E. Fadul,
Brock C. Christensen

Affiliations

Kevin C. Johnson: Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth
E. Andres Houseman: Department of Biostatistics, College of Public Health and Human Sciences, Oregon State University
Jessica E. King: Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth
Katharine M. von Herrmann: Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth
Camilo E. Fadul: Department of Neurology, University of Virginia
Brock C. Christensen: Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth

DOI: https://doi.org/10.1038/ncomms13177
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

Read online

Glioblastomas have distorted epigenomes. Here, the authors compare the genome-wide profiles of 5-methylcytosine and 5- hydroxymethylcytosine in glioblastoma and prefrontal cortex tissue reporting a correlation between these profiles and patients’ prognosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal