Corynanthean-Epicatechin Flavoalkaloids from <i>Corynanthe pachyceras</i>
Tapé Kouamé,
Aboua Timothée Okpekon,
Nicaise F. Bony,
Amon Diane N’Tamon,
Jean-François Gallard,
Somia Rharrabti,
Karine Leblanc,
Elisabeth Mouray,
Philippe Grellier,
Pierre Champy,
Mehdi A. Beniddir,
Pierre Le Pogam
Affiliations
Tapé Kouamé
Université Paris-Saclay, CNRS, BioCIS, 92290 Châtenay-Malabry, France
Aboua Timothée Okpekon
Laboratoire de Chimie Organique et de Substances Naturelles (LCOSN), UFR Sciences des Structures de la Matière et Technologie, Univ. FHB, 22 BP 582 Abidjan 22, Côte d’Ivoire, France
Nicaise F. Bony
Département de Chimie Analytique, Minérale et Générale, Technologie Alimentaire, UFR Sciences Pharmaceutiques et Biologiques, Univ. FHB, 06 B. P. 2256 Abidjan 06, Côte d’Ivoire, France
Amon Diane N’Tamon
Université Paris-Saclay, CNRS, BioCIS, 92290 Châtenay-Malabry, France
Jean-François Gallard
Institut de Chimie des Substances Naturelles, CNRS, ICSN UPR 2301, Université Paris-Saclay, 21 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France
Somia Rharrabti
Université Paris-Saclay, CNRS, BioCIS, 92290 Châtenay-Malabry, France
Karine Leblanc
Université Paris-Saclay, CNRS, BioCIS, 92290 Châtenay-Malabry, France
Elisabeth Mouray
Muséum National d′Histoire Naturelle, Unité Molécules de Communication et Adaptation des Micro-organismes, UMR7245, CP54, 57 Rue Cuvier, 75005 Paris, France
Philippe Grellier
Muséum National d′Histoire Naturelle, Unité Molécules de Communication et Adaptation des Micro-organismes, UMR7245, CP54, 57 Rue Cuvier, 75005 Paris, France
Pierre Champy
Université Paris-Saclay, CNRS, BioCIS, 92290 Châtenay-Malabry, France
Mehdi A. Beniddir
Université Paris-Saclay, CNRS, BioCIS, 92290 Châtenay-Malabry, France
Pierre Le Pogam
Université Paris-Saclay, CNRS, BioCIS, 92290 Châtenay-Malabry, France
Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/2D NMR data. These compounds represent the first examples of corynanthean-type alkaloids tethered with a flavonoid. Epicatechocorynantheidine notably instigated two connections between the monoterpene indole alkaloid and the flavonoid, yielding an unprecedented octacyclic appendage. These flavoalkaloids exerted moderate antiplasmodial activities.
