OncoTargets and Therapy (Jul 2020)
Clinical Significance of ZNF711 in Human Breast Cancer
Abstract
Xiaoyan Li,1 Liu Tian,2 Lina Zhang,1 Baojin Xu,3 Yong Zhang,1 Qiang Li1 1Department of Pathology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, People’s Republic of China; 2Psychiatry and Mental Health Center, Shenyang Mental Health Center, Shenyang, Liaoning 110168, People’s Republic of China; 3Departments of Breast Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, People’s Republic of ChinaCorrespondence: Qiang LiDepartment of Pathology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Dadong District, Shenyang City, Liaoning 110042, People’s Republic of ChinaTel/ Fax +86 24-31516152Email [email protected]: To investigate the clinicopathologic and prognostic significance of the zinc-finger protein 711 (ZNF711) in breast cancer (BCa).Materials and Methods: The relevance of ZNF711 in BCa was analyzed using bioinformatics. The expression of ZNF711 was detected by immunohistochemistry in paraffin blocks of BCa. To evaluate its clinical significance, the correlation between the expression of ZNF711 and BCa clinical indicators, including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2), was analyzed. Finally, the Kaplan–Meier method was applied to explore the prognostic value of ZNF711.Results: ZNF711 expression was decreased in BCa and was negatively correlated with ER expression (P < 0.05) and positively correlated with HER-2 expression (P < 0.01), but there was no significant correlation between ZNF711 and PR expression. ZNF711 expression was not correlated with age, tumor diameter, or lymph node metastasis; however, ZNF711 expression was correlated with staging in BCa. Survival analysis results showed that the ZNF711-positive group patients had a poorer prognosis compared with the ZNF711-negative group.Conclusion: The expression of ZNF711 was deceased in BCa and closely related to ER and HER-2 expression. Therefore, ZNF711 could not only serve as a predictor of BCa with poor prognosis but also as a potential biomarker for targeted therapy.Keywords: breast cancer, zinc-finger protein 711, ER, HER-2
