Cerebrovascular Diseases Extra (Dec 2013)

Trends of the Incidence of Ischemic Stroke Thrombolysis over Seven Years and One-Year Outcome: A Population-Based Study in Joinville, Brazil

  • Carla H.C. Moro,
  • Anderson R.R. Gonçalves,
  • Alexandre L. Longo,
  • Patricia G. Fonseca,
  • Rodrigo Harger,
  • Débora B. Gomes,
  • Mariana C. Ramos,
  • Aline L.G. Estevam,
  • Cristiane S. Fissmer,
  • Adriana C. Garcia,
  • Vivian Nagel,
  • Norberto L. Cabral

DOI
https://doi.org/10.1159/000356984
Journal volume & issue
Vol. 3, no. 1
pp. 156 – 166

Abstract

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Background: In a population-based setting, we aimed to measure the incidence trends of ischemic stroke (IS) thrombolysis, thrombolysis times, proportion of symptomatic intracerebral hemorrhage (sICH), 30-day case fatality and functional outcomes. We also compared the 12-month functional status between thrombolyzed and nonthrombolyzed patients. Methods: Using data from the Joinville Population-Based Stroke Registry, we prospectively ascertained a cohort of all thrombolyses done in Joinville citizens, Southern Brazil, from 2005 to 2011. For the definition of sICH we used European Cooperative Acute Stroke Study (ECASS) II criteria. Results: Over 7 years, 6% (220/3,552) of all IS were thrombolyzed. The thrombolysis incidence increased from 1.4 [95% confidence interval (CI), 0.6-2.9] in 2005 to 9.8 (7.3-12.9) per 100,000 population in 2011 (p Conclusion: In a population setting of a middle income country, the thrombolysis incidence and outcomes were similar to those of other well-structured services. After 1 year, patients thrombolyzed in the 4.5-hour time window had a better outcome. More than proportions, rates provide additional information and could be used to benchmark services against others.

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