Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress

Stefan Rudloff; Mathilde Janot; Stephane Rodriguez; Kevin Dessalle; Willi Jahnen-Dechent; Uyen Huynh-Do

doi:10.1038/s41467-020-20832-7

Nature Communications (Jan 2021)

Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress

Stefan Rudloff,
Mathilde Janot,
Stephane Rodriguez,
Kevin Dessalle,
Willi Jahnen-Dechent,
Uyen Huynh-Do

Affiliations

Stefan Rudloff: Department of Nephrology and Hypertension, Bern University Hospital
Mathilde Janot: Department of Nephrology and Hypertension, Bern University Hospital
Stephane Rodriguez: Department of Nephrology and Hypertension, Bern University Hospital
Kevin Dessalle: Department of Nephrology and Hypertension, Bern University Hospital
Willi Jahnen-Dechent: Helmholtz-Institute for Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University Medical Faculty
Uyen Huynh-Do: Department of Nephrology and Hypertension, Bern University Hospital

DOI: https://doi.org/10.1038/s41467-020-20832-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Intrauterine growth restriction is associated with increased risk for chronic diseases in adults. Here the authors identify fetuin-A as a HIF target gene and describe its protective role in the kidney, counteracting disease mechanisms such as calcification, macrophage polarization, and fibrosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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