Drug-Induced Bullous Haemorrhagic Dermatosis: Insights from a Case Series

Abstract

Bullous haemorrhagic dermatosis (BHD), a distinctive non-immune cutaneous eruption, manifests as the formation of haemorrhagic bullae on the skin. While it is an uncommon dermatologic entity, its clinical significance is underscored by its association with various medications, including anticoagulants and antiplatelet agents, as well as chemotherapeutic drugs. Clinical or pathological signs of inflammation are usually absent. The pathophysiology of BHD involves the disruption of normal skin integrity, leading to the development of bullae containing blood. These bullae typically appear at sites distant from the initial lesion or injection site, posing challenges in diagnosis and management. Here we discuss three such cases and their presenting features. Keywords: Bullous Haemorrhagic Dermatosis, Cutaneous Adverse Drug Reactions, Histopathology