Dengue Virus Serotype 1 Effects on Mosquito Survival Differ among Geographically Distinct <i>Aedes aegypti</i> Populations
Milan S. G. Keirsebelik,
Mariana R. David,
Márcio Galvão Pavan,
Dinair Couto-Lima,
Miriam Palomino,
Rafi Ur Rahman,
Ary A. Hoffmann,
Ana C. Bahia,
Guy Caljon,
Rafael Maciel-de-Freitas
Affiliations
Milan S. G. Keirsebelik
Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil
Mariana R. David
Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil
Márcio Galvão Pavan
Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil
Dinair Couto-Lima
Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil
Miriam Palomino
Laboratorio de Referência Nacional de Entomologia, Centro Nacional de Salud Pública, Instituto Nacional de Salud, Lima 15072, Peru
Rafi Ur Rahman
Department of Biosciences, COMSATS University, Islamabad 45550, Pakistan
Ary A. Hoffmann
Pest and Environmental Adaptation Research Group, Bio21 Institute, School of BioSciences, The University of Melbourne, 3052 Melbourne, Australia
Ana C. Bahia
Laboratório de Bioquímica de Insetos e Parasitos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21040-900, Brazil
Guy Caljon
Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, 1, 2610 Wilrijk-Antwerp, Belgium
Rafael Maciel-de-Freitas
Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, Brazil
The mosquito Aedes aegypti is distributed worldwide and is recognized as the primary vector for dengue in numerous countries. To investigate whether the fitness cost of a single DENV-1 isolate varies among populations, we selected four Ae. aegypti populations from distinct localities: Australia (AUS), Brazil (BRA), Pakistan (PAK), and Peru (PER). Utilizing simple methodologies, we concurrently assessed survival rates and fecundity. Overall, DENV-1 infection led to a significant decrease in mosquito survival rates, with the exception of the PER population. Furthermore, infected Ae. aegypti from PAK, the population with the lowest infection rate among those tested, exhibited a noteworthy reduction in egg laying. These findings collectively suggest that local mosquito-virus adaptations may influence dengue transmission in endemic settings.
