Atherogenic hyperadrenoreactivity in men with arterial hypertension

Abstract

Aim. То assess the dynamics and interrelations of neuro-humoral and lipid profiles in men with arterial hypertension (AH), based on serum leptin level, adrenoreactivity and lipid profile (ГР) measurement.Material and methods. The study included 60 AH patients aged 30—60 years: 30 men with Stage I-II AH, risk 1—3, and 30 men with AH and diabetes mellitus (DM). In all participants, body mass index (BMI), serum levels of leptin, total cholesterol (TCH), high, low and very low density lipoprotein CH (HDT, TDT and VTDT-CH) were measured, with atherogenicity coefficient (AC) calculated. Sympatho-adrenal system activity was assessed by beta-adrenoreactivity evaluation (red blood cell osmo-resistance in beta-adrenoblocker test).Results. In patients with AH and increased BMI, TP changes manifested in increased TCH, TDT-CH, VTDT-CH and AC levels. In DM-free AH individuals, adrenoreactivity directly correlated with atherogenic lipoprotein levels.Conclusion. In AH patients, atherogenic hyperadrenoreactivity is one of the mechanisms for atherosclerosis development and progression.

Keywords

• артериальная гипертония
• лептин
• адренореактивность
• липопротеины