Organization and dynamics of SNARE proteins in the presynaptic membrane

Frontiers in Physiology. 2015;6 DOI 10.3389/fphys.2015.00089

 

Journal Homepage

Journal Title: Frontiers in Physiology

ISSN: 1664-042X (Online)

Publisher: Frontiers Media S.A.

LCC Subject Category: Science: Physiology

Country of publisher: Switzerland

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB, XML

 

AUTHORS

Dragomir eMilovanovic (Max Planck Institute for Biophysical Chemistry)
Reinhard eJahn (Max Planck Institute for Biophysical Chemistry)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 14 weeks

 

Abstract | Full Text

Our view of the lateral organization of lipids and proteins in the plasma membrane has evolved substantially in the last few decades. It is widely accepted that many, if not all, plasma membrane proteins and lipids are organized in specific domains. These domains vary widely in size, composition, and stability, and they represent platforms governing diverse cell functions. The presynaptic plasma membrane is a well-studied example of a membrane which undergoes rearrangements, especially during exo- and endocytosis. Many proteins and lipids involved in presynaptic function are known, and major efforts have been made to understand their spatial organization and dynamics. Here, we focus on the mechanisms underlying the organization of SNAREs, the key proteins of the fusion machinery, in distinct domains, and we discuss the functional significance of these clusters.