Future Journal of Pharmaceutical Sciences (Aug 2023)

Suzuki–Miyaura cross-couplings for alkyl boron reagent: recent developments—a review

  • Adnan Ahmed,
  • Irfan Mushtaq,
  • Sampath Chinnam

DOI
https://doi.org/10.1186/s43094-023-00520-1
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 22

Abstract

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Abstract In the history of catalysis and organic synthesis, boric chemistry has been developed into one of the most varied and practical disciplines. Several useful Suzuki–Miyaura cross-coupling (SMC) reactions as well as hydroborylation reactions are regarded the essential tools inside the chemical synthesis toolkit accompanied by researchers of the industry or the academia. Novel synthesis of the less electrically and sterically ongoing carbon–boron synthetic reagents is carried out to ensure a unique coupling reaction utilizing metals along with these reagents which draws considerable interest in accelerating the discovery of creative uses for otherwise difficult organic adducts in many disciplines. This article details the noteworthy advancements in the use of traditional metal-catalyzed carbon–carbon coupling processes with cutting-edge coupling partners such as carbon–boron reagents often the beta-alkyl Suzuki–Miyaura coupling since 2001. The current review covers alkylboranes, organotrifluoroborates, 9-BBN, alkylboronic acids and boronic esters as useful reagents in SMCs that will help synthetic chemists in developing new compounds. Graphical Abstract

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