International Journal of COPD (Feb 2023)

The Role of Glucagon-Like Peptide-1 Receptor Agonists in Chronic Obstructive Pulmonary Disease

  • Wang W,
  • Mei A,
  • Qian H,
  • Li D,
  • Xu H,
  • Chen J,
  • Yang H,
  • Min X,
  • Li C,
  • Cheng L,
  • Chen J

Journal volume & issue
Vol. Volume 18
pp. 129 – 137

Abstract

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Wenwen Wang,1,* Aihua Mei,1,* Hang Qian,1,* Dongfeng Li,1 Hao Xu,1 Jishun Chen,1 Handong Yang,1 Xinwen Min,1 Chunlei Li,1 Li Cheng,1 Jun Chen1,2 1Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Hubei Key Laboratory of Wudang Local Chinese Medicine Research (Hubei University of Medicine), Shiyan, People’s Republic of China; 2Institute of Virology, Hubei University of Medicine, Shiyan, Hubei, 442000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun Chen; Li Cheng, Sinopharm General Dongfeng Hospital, Hubei University of Medicine, 16 Daling Road, Shiyan, Hubei, 442000, People’s Republic of China, Email [email protected]; [email protected]: Chronic obstructive pulmonary disease (COPD) is one of the common diseases of the respiratory system. As the disease recurs, damage to the airways and lung tissue gradually worsens, leading to a progressive decline in lung function, affecting the patient’s workforce and quality of life, and causing a huge social and economic burden. Diabetes is a common comorbidity of COPD and patients with COPD are at increased risk of developing diabetes, while hyperglycemia can also reduce lung function and contribute to the progression and poor prognosis of COPD. Glucagon-like peptide-1 receptor agonist (GLP-1RA) is a new type of hypoglycemic agent that has been shown to regulate blood glucose levels, reduce inflammatory responses and oxidative stress, and regulate lipid metabolism, among other effects. GLP-1RAs may benefit COPD patients by acting directly on the lung from mechanisms such as reducing the inflammatory response, improving oxidative stress, regulating protease/anti-protease imbalance, improving airway mucus homeostasis, and reducing airway remodeling. This study provides a review of the potential role of GLP-1RAs in COPD and offers new ideas for the prevention and treatment of COPD.Keywords: glucagon-like peptide 1 receptor agonist, chronic obstructive pulmonary disease, clinical application

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