Competing risk analysis of primary tracheal carcinoma based on SEER database

Cancer Management and Research. 2019;Volume 11:1059-1065

 

Journal Homepage

Journal Title: Cancer Management and Research

ISSN: 1179-1322 (Online)

Publisher: Dove Medical Press

LCC Subject Category: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Gao HX
He X
Du JF
Yang SH
Wang Y
Zhang JW
Zhao CN

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 16 weeks

 

Abstract | Full Text

HongXiang Gao,1 Xuan He,1 JianFei Du,1 SanHu Yang,2 Yang Wang,1 JunWei Zhang,1 ChenNian Zhao1 1Department of Oncology, Chang’An Hospital, Xi’an, Shaanxi, China; 2Department of Thoracic Surgery, Tangdu Hospital, Xi’an, Shaanxi, China Purpose: To analyze the prognostic factors of primary tracheal carcinoma. Patients and methods: All patients of primary tracheal carcinoma were extracted from the Surveillance, Epidemiology, and End Results database during 1973–2015. The potential prognostic factors were analyzed by using the competing risk analysis of R statistical software. Results: A total of 485 eligible patients were enrolled. The univariate analysis indicated that age, sex, diagnostic confirmation, extension, lymph node, metastasis, multiple primary tumors, primary site surgery, and lymph node dissection were statistically significant for the patients’ death due to tracheal tumor. The multivariate analysis indicated that age (P=0.0000, CI: 1.0255–1.0630), lymph node (P=0.0000, CI: 1.6031–3.4890), metastasis (P=0.0100, CI: 1.1342–2.5790), multiple primary tumors (P=0.0000, CI: 0.0276–0.1090), and primary site surgery (P=0.0001, CI: 0.3565–0.7110) were independent prognostic factors affecting survival, and there were significant differences in the stratification of each prognostic factors. Conclusion: Age, lymph node, metastasis, multiple primary tumors, and primary site surgery were independent prognostic factors of primary tracheal carcinoma. Keywords: primary tracheal carcinoma, SEER, prognostic factor, competing risk analysis