Nature Communications (Feb 2017)
Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo
Abstract
Goadsporin is an antibacterial peptide highly customized by multiple post-translational modifying enzymes. Here, the authors dissect its biosynthetic pathway byin vitro reconstitution and use their insights to produce goadsporin analogues in vitro and in vivo.