Design and release kinetics of liposomes containing abiraterone acetate for treatment of prostate cancer

Abstract

The present work deals with the preparation and in vitro evaluation of liposomal formulations of abiraterone acetate. In the present work, abiraterone acetate-loaded liposomal formulation was formulated by thin lipid film method. The prepared liposomal formulation of abiraterone acetate was evaluated by drug content estimation, particle size measurement, in vitro drug release and release kinetics studies. Dried samples of liposomal suspension of abiraterone acetate were characterized by scanning electron microscopy (SEM) analysis. The drug contents of liposomal formulations were within the ranges, 6.06 ± 0.43 to 10.55 ± 1.04 mg/ml. In vitro drug release from these liposomal formulations was found to be sustained over 4 h, which followed the zero order model (R2 = 0.8940 to 0.9884) over 4 h. After storage of 1 month at 4 °C temperature, the best liposomal formulation (prepared using 100 mg lecithin) was found stable enough. These liposomal formulations of abiraterone acetate can be formulated for parenteral application to treat advanced prostate cancer.

Keywords

• Liposomes
• Abiraterone acetate
• Cholesterol
• Lecithin
• Drug release