P3.13 ASSOCIATIONS OF CENTRAL AND PERIPHERAL PULSE PRESSURE WITH HEART STRUCTURE, SYSTOLIC AND DIASTOLIC FUNCTION IN ADOLESCENCE: FINDINGS FROM A GENERAL POPULATION COHORT

Abstract

Background: In adults central blood pressure has stronger associations with cardiovascular outcomes than peripheral blood pressure, with some evidence that this difference is greater in mid- than older-aged adults. The relationship of central blood pressure to cardiovascular structure and function in adolescence is unclear. Aim: To compare associations of central and peripheral pulse pressure (PP) with cardiac structure and left ventricular function in a general population of adolescents. Methods: 1,421 (17y; 45% males) participants in the Avon Longitudinal Study of Parents and Children had measurements of peripheral and central blood pressure using Omron705 IT and Sphygmocor devices and echocardiography using a HDI 5000 ultrasound system. Results: Central to peripheral amplification was 21 mmHg (95% CI: 20, 21). Central and peripheral PP were positively associated with left ventricular mass index (LVMI), mitral E/A ratio, left atrial size and inversely associated with s′ even when adjusting for age, sex, DEXA determined fat mass and physical activity (Table 1); with consistently greater associations noted for cPP. Neither central nor peripheral PP were associated with relative wall thickness, midwall fractional shortening, ejection fraction e’ or E/e′. Conclusions: Central PP is more strongly associated with measures of cardiac structure and function than peripheral PP in adolescence. Previous studies are likely to have underestimated the effect of PP on cardiac structure and function in children and adolescents based on peripheral measurements. P3.14 Withdrawn by author