Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues

Meng Zhao; Yi Xiao; Satoshi Otsuka; Yoichi Nakao; Yoichi Nakao; Yian Guo; Tao Ye; Tao Ye

doi:10.3389/fchem.2020.00410

Frontiers in Chemistry (May 2020)

Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues

Meng Zhao,
Yi Xiao,
Satoshi Otsuka,
Yoichi Nakao,
Yoichi Nakao,
Yian Guo,
Tao Ye,
Tao Ye

Affiliations

Meng Zhao: State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, China
Yi Xiao: State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, China
Satoshi Otsuka: Research Institute for Science and Engineering, Waseda University, Tokyo, Japan
Yoichi Nakao: Research Institute for Science and Engineering, Waseda University, Tokyo, Japan
Yoichi Nakao: Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
Yian Guo: State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, China
Tao Ye: State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, China
Tao Ye: Tsinghua Shenzhen International Graduate School, Xili, Shenzhen, China

DOI: https://doi.org/10.3389/fchem.2020.00410
Journal volume & issue: Vol. 8

Abstract

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Kakeromamide A (1), the first marine cyclopeptide inducing neural stem cells differentiation into astrocytes, was synthesized in 12 longest linear steps and 14% overall yield. Using this synthetic approach, four analogs of kakeromamide A were prepared and evaluated for neural differentiation- modulating activity.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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Abstract

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