Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9

Lintao Liu; Enguang Bi; Xingzhe Ma; Wei Xiong; Jianfei Qian; Lingqun Ye; Pan Su; Qiang Wang; Liuling Xiao; Maojie Yang; Yong Lu; Qing Yi

doi:10.1038/s41467-020-19672-2

Nature Communications (Nov 2020)

Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9

Lintao Liu,
Enguang Bi,
Xingzhe Ma,
Wei Xiong,
Jianfei Qian,
Lingqun Ye,
Pan Su,
Qiang Wang,
Liuling Xiao,
Maojie Yang,
Yong Lu,
Qing Yi

Affiliations

Lintao Liu: Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist
Enguang Bi: Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist
Xingzhe Ma: Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist
Wei Xiong: Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist
Jianfei Qian: Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist
Lingqun Ye: Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist
Pan Su: Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist
Qiang Wang: Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist
Liuling Xiao: Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist
Maojie Yang: Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist
Yong Lu: Comprehensive Cancer Center, Wake Forest Baptist Health, and Department of Microbiology & Immunology, Wake Forest School of Medicine
Qing Yi: Center for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center/Houston Methodist Research Institute, Houston Methodist

DOI: https://doi.org/10.1038/s41467-020-19672-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Antigen-specific IL9-secreting CD4 Th9 and CD8 Tc9 cells have been previously characterized for their anti-tumour properties. Here, the authors show that ex vivo polarized Th9/Tc9 human CAR-T cells display increased anti-tumor activity in pre-clinical haematological and solid cancer models compared to conventional IL-2 activated CAR-T cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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