Current Perspectives on the Systemic Management of Atopic Dermatitis

Abstract

Danielle R Davari, Elizabeth L Nieman, Diana B McShane, Dean S Morrell Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill, NC, USACorrespondence: Dean S MorrellDepartment of Dermatology, University of North Carolina School of Medicine, Chapel Hill, NC, USATel [phone]Fax [phone]Email [email protected]: Atopic dermatitis (AD) is a common disease of childhood, and some patients experience a prolonged clinical course into adolescence and adulthood. Systemic management is required when AD is not adequately controlled with topical medications. Our aim is to provide a comprehensive review of commonly used systemic immunomodulating agents in childhood and adult AD, including cyclosporine A (CsA), azathioprine (AZA), methotrexate (MTX) and mycophenolate mofetil (MMF), which are prescribed off-label in the United States, as well as dupilumab, an FDA-approved biologic. We will also provide a brief overview of emerging systemic therapies currently under investigation.Keywords: eczema, adults, pediatric, treatment, dupilumab

Keywords

• eczema
• adults
• pediatric
• treatment
• dupilumab