Indonesian Journal of Pharmacy (Apr 2010)
Synthesis of Tetrahydro Pentagavunon-0
Abstract
Curcumin, tetrahydrocurcumin, and monoketone curcumin analogue, pentagamavunone-0 (PGV-0), have been investigated as antioxidant, antiinflammatory and anticancer. This research was aimed to synthesise the Tetrahydropentagamavunone-0 (THPGV-0) compound which assumed as an active metabolite of PGV-0. The hydrogenation reaction was applied to the synthesis of THPGV-0 from PGV-0 using Pd/C 10 % as catalyst at room temperature. The structure elucidation was analysed by using spectroscophy method. The synthetic result showed that THPGV-0 asa white crystalline powder in 25 % with melting point about 122-123 oC.
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