Visible-Light-Assisted Photoelectrochemical Biosensing of Uric Acid Using Metal-Free Graphene Oxide Nanoribbons
Chia-Liang Sun,
Cheng-Hsuan Lin,
Chia-Heng Kuo,
Chia-Wei Huang,
Duc Dung Nguyen,
Tsu-Chin Chou,
Cheng-Ying Chen,
Yu-Jen Lu
Affiliations
Chia-Liang Sun
Biomedical Engineering Research Center, Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan City 333323, Taiwan
Cheng-Hsuan Lin
Biomedical Engineering Research Center, Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan City 333323, Taiwan
Chia-Heng Kuo
Biomedical Engineering Research Center, Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan City 333323, Taiwan
Chia-Wei Huang
Biomedical Engineering Research Center, Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan City 333323, Taiwan
Duc Dung Nguyen
Center for High Technology Development, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam
Tsu-Chin Chou
Institute of Analytical and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan
Cheng-Ying Chen
Center for Plasma and Thin Film Technologies (CPTFT), Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan
Yu-Jen Lu
Department of Neurosurgery, Linkou Chang Gung Memorial Hospital, Taoyuan City 333423, Taiwan
In this study, we demonstrate the visible-light-assisted photoelectrochemical (PEC) biosensing of uric acid (UA) by using graphene oxide nanoribbons (GONRs) as PEC electrode materials. Specifically, GONRs with controlled properties were synthesized by the microwave-assisted exfoliation of multi-walled carbon nanotubes. For the detection of UA, GONRs were adopted to modify either a screen-printed carbon electrode (SPCE) or a glassy carbon electrode (GCE). Cyclic voltammetry analyses indicated that all Faradaic currents of UA oxidation on GONRs with different unzipping/exfoliating levels on SPCE increased by more than 20.0% under AM 1.5 irradiation. Among these, the GONRs synthesized under a microwave power of 200 W, namely GONR(200 W), exhibited the highest increase in Faradaic current. Notably, the GONR(200 W)/GCE electrodes revealed a remarkable elevation (~40.0%) of the Faradaic current when irradiated by light-emitting diode (LED) light sources under an intensity of illumination of 80 mW/cm2. Therefore, it is believed that our GONRs hold great potential for developing a novel platform for PEC biosensing.
