Blood Investigation and Cardiac Markers: The Key Role to Rule Out Hospital Outcome of Myocardial Infraction in Tertiary Cardiac Care Centre

Abstract

Background: In-hospital mortality varies substantially across hospitals after myocardial infarction. This study is intended for physicians, nurses, and allied healthcare personnel who care for patients with suspected or established acute myocardial infarction (MI) in emergency department and to find out the association between the CBCs, cardiac markers and other biochemical tests with the severity of MI. Method: In this retrospective study, data were collected of 190 patients came in the emergency department period of one month August 2023 with chest pain diagnosed as myocardial infarction. All patient’s Lipid profile, HbA1c, Total Count, Absolute Neutrophil Count (ANC), Neutrophil Counts, Lymphocyte Counts, Neutrophil to Lymphocytes ratio (NLR), Immature Granulocyte % (IG%), Absolute Immature Granulocyte Count (IG#), Platelet Count, CPK-Mb, Troponin I and Pressure were noted in first 24 hrs of time. Result: In this study we have found that Total lymphocyte count (AUC=0.83 Sensitivity-Specificity=89.5-71.3, p=<0.001), CPK-MB (AUC=0.67, Sensitivity-Specificity=89.5-43.3, p=0.006), Absolute neutrophil counts (AUC=0.83, Sensitivity-Specificity=89.5-67.3, p=<0.001), Neutrophils (AUC=0.75, Sensitivity-Specificity=89.5-60.2, p=<0.001), and Lymphocyte (AUC=0.74, Sensitivity-Specificity=73.7-69.6, p=<0.001), are the significantly associated with worsen outcome in patients with myocardial infarction. Conclusion: Total lymphocyte count, CPK-MB, Absolute neutrophil counts, Neutrophils and Lymphocyte are the significant predictor, indicate an increased risk of death in patients with myocardial infarction in emergency department. Keywords: Myocardial infarction, Cardiac Biomarkers, Blood Investigation