Recent process of using nanoparticles in the T cell-based immunometabolic therapy

Abstract

Immunotherapy is currently the main treatment for malignant tumors by activating immune cell. Metabolic reprogramming in tumor microenvironment can greatly affect the function of immune cell, and T cell is the main anti-tumor effector cell. Therefore, the T cell-based immunometabolic therapy can improve clinical efficacy. In T cell-based immunometabolic therapy, regular agents in conventional forms are difficult to achieve the intended efficacy due to poor tumor permeability and low cellular uptake. Nanoparticle-based strategy can serve as the optimal targeted drug delivery system due to co-encapsulation of multiple therapeutic agents and stable loading. Here, we intend to summarize examples of nanoparticles in the T cell-based immunometabolic therapy, and provide a comprehensive and helpful review by covering notable and vital applications of nanotechnology-based strategies for T cell-based immunometabolic therapy.

Keywords

• nanoparticles
• immunotherapy
• t cell
• immunometabolism