The late stage of COPI vesicle fission requires shorter forms of phosphatidic acid and diacylglycerol

Seung-Yeol Park; Jia-Shu Yang; Zhen Li; Pan Deng; Xiaohong Zhu; David Young; Maria Ericsson; Ruben L. H. Andringa; Adriaan J. Minnaard; Chunmei Zhu; Fei Sun; D. Branch Moody; Andrew J. Morris; Jun Fan; Victor W. Hsu

doi:10.1038/s41467-019-11324-4

Nature Communications (Jul 2019)

The late stage of COPI vesicle fission requires shorter forms of phosphatidic acid and diacylglycerol

Seung-Yeol Park,
Jia-Shu Yang,
Zhen Li,
Pan Deng,
Xiaohong Zhu,
David Young,
Maria Ericsson,
Ruben L. H. Andringa,
Adriaan J. Minnaard,
Chunmei Zhu,
Fei Sun,
D. Branch Moody,
Andrew J. Morris,
Jun Fan,
Victor W. Hsu

Affiliations

Seung-Yeol Park: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School
Jia-Shu Yang: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School
Zhen Li: Department of Materials Science and Engineering, City University of Hong Kong
Pan Deng: Division of Cardiovascular Medicine, Department of Medicine, University of Kentucky
Xiaohong Zhu: Department of Materials Science and Engineering, City University of Hong Kong
David Young: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School
Maria Ericsson: Department of Cell Biology, Harvard Medical School
Ruben L. H. Andringa: Stratingh Institute for Chemistry, University of Groningen
Adriaan J. Minnaard: Stratingh Institute for Chemistry, University of Groningen
Chunmei Zhu: National Key Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Fei Sun: National Key Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
D. Branch Moody: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School
Andrew J. Morris: Division of Cardiovascular Medicine, Department of Medicine, University of Kentucky
Jun Fan: Department of Materials Science and Engineering, City University of Hong Kong
Victor W. Hsu: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-019-11324-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Phosphatidic acid and diacylglycerol are required for COPI vesicle fission. Here, the authors find that shorter forms of these lipids promote the late stage of COPI vesicle fission, further suggesting how lipid geometry contributes to membrane deformation in driving fission.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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