Data supporting the role of Fyn in embryonic sciatic nerve fasciculation
Tomohiro Torii,
Yuki Miyamoto,
Kazuko Kawahara,
Akito Tanoue,
Yoichi Seki,
Takako Morimoto,
Masahiro Yamamoto,
Junji Yamauchi
Affiliations
Tomohiro Torii
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Yuki Miyamoto
Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan
Kazuko Kawahara
Laboratory of Molecular Pharmacology, Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan
Akito Tanoue
Laboratory of Molecular Pharmacology, Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan
Yoichi Seki
Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan
Takako Morimoto
Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan
Masahiro Yamamoto
Tsumura Research Laboratories, Tsumura & Co., Inashiki, Ibaraki 200-1192, Japan
Junji Yamauchi
Laboratory of Molecular Neuroscience and Neurology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan
Fyn is the cytoplasmic tyrosine kinase that has critical roles in many aspects of biological functions. In the central [1] and peripheral nervous systems [2,3], Fyn plays the key role in initiating myelination by myelin-forming glial cells (Schwann cells and oligodendrocytes). Herein we provide the data regarding the role of Fyn in fasciculation and branching of embryonic peripheral nerves.
