Nature Communications (May 2020)
Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction
- Tu’uhevaha J. Kaitu’u-Lino,
- Teresa M. MacDonald,
- Ping Cannon,
- Tuong-Vi Nguyen,
- Richard J. Hiscock,
- Nick Haan,
- Jenny E. Myers,
- Roxanne Hastie,
- Kirsten M. Dane,
- Anna L. Middleton,
- Intissar Bittar,
- Amanda N. Sferruzzi-Perri,
- Natasha Pritchard,
- Alesia Harper,
- Natalie J. Hannan,
- Valerie Kyritsis,
- Nick Crinis,
- Lisa Hui,
- Susan P. Walker,
- Stephen Tong
Affiliations
- Tu’uhevaha J. Kaitu’u-Lino
- Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne
- Teresa M. MacDonald
- Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne
- Ping Cannon
- Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne
- Tuong-Vi Nguyen
- Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne
- Richard J. Hiscock
- Mercy Perinatal, Mercy Hospital for Women
- Nick Haan
- Foresight Health
- Jenny E. Myers
- University of Manchester, Manchester Academic Health Science Centre, St Mary’s Hospital
- Roxanne Hastie
- Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne
- Kirsten M. Dane
- Mercy Perinatal, Mercy Hospital for Women
- Anna L. Middleton
- Mercy Perinatal, Mercy Hospital for Women
- Intissar Bittar
- Pathology Department, Austin Health
- Amanda N. Sferruzzi-Perri
- Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge
- Natasha Pritchard
- Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne
- Alesia Harper
- Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne
- Natalie J. Hannan
- Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne
- Valerie Kyritsis
- Mercy Perinatal, Mercy Hospital for Women
- Nick Crinis
- Pathology Department, Austin Health
- Lisa Hui
- Mercy Perinatal, Mercy Hospital for Women
- Susan P. Walker
- Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne
- Stephen Tong
- Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne
- DOI
- https://doi.org/10.1038/s41467-020-16346-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
There are no reliable tests for placental insufficiency, which can lead to fetal growth restriction and stillbirth. Here the authors demonstrate that low levels of circulating SPINT1 are associated to low birthweight, and several ultrasound and neonatal anthropomorphic indicators of placental insufficiency.
