Effect of Ethanolic Extract of Emblica officinalis (Amla) on Glucose Homeostasis in Rats Fed with High Fat Diet

Abstract

Background: Emblica officinalis contains many biological active components which are found to have some medicinal properties against diseases. Aim and Objectives: To assess hypolipidemic and glucose regulatory actions of Ethanolic Extract of Emblica officinalis (EEO) on High Fat Diet (HFD) fed experimental rats. Material and Methods: Twenty four rats were divided into four groups, having six rats in each group as following; Group I- Control (20% fat); Group II (EEO 100 mg/kg/b w); Group III (30% fat) and Group IV (30% fat + EEO 100 mg/kg/b w). The treatment was continued for 21 days. Gravimetric parameters and lipid profiles of all the groups were measured. Oral Glucose Tolerance Test (OGTT), fasting and postprandial glucose and fasting insulin levels were estimated. Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was calculated. Statistical analysis was done. Results: Significant alteration in serum lipid profile, fasting and post prandial blood glucose levels and fasting insulin level were observed in rats of Group III fed with high fat diet. Supplementation of EEO improved both of glycemic and lipid profiles in rats of Group IV fed with high fat diet. Conclusion: Results from the study indicate the beneficial role of EEO on dyslipidemia and glucose homeostasis in rats treated with high fat diet.

Keywords

• Emblica officinalis
• Dyslipidemia
• Oral Glucose Tolerance Test
• Homeostasis Model Assessment of Insulin Resistance