Acta Medica Leopoliensia (Aug 2017)

Differential diagnostic features of Metabolic Syndrome with obesity in the presence or absence of chronic coronary artery disease considering gender differences

  • R.Ya. Dutka,
  • N.V. Chmyr

DOI
https://doi.org/10.25040/aml2017.03.010
Journal volume & issue
Vol. 23, no. 3
pp. 10 – 15

Abstract

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Aim. The differences between metabolic syndrome (MS) with obesity with or without comorbid pathology (chronic coronary artery disease i.e. CAD) were explicated in the research. Material and Methods. 126 patients with MS were examined. MS without chronic CAD was diagnosed in 82 patients and MS with chronic CAD was diagnosed in 44 patients. Levels of lipid spectrum, cortisol, prolactin, thyroid-stimulating hormone (TSH), free thyroxinе (fT4), glycosylated hemoglobin (HbAlc), and glucose were determined in all patients. Ultrasonography of the heart was taken into account. Results and Discussion. Increased levels of cortisol, TSH and prolactin (only in women) were observed in patients with MS without chronic CAD. Normal levels of cortisol and prolactin were observed in the patients with MS and chronic CAD simultaneously with increase of TSH levels in men and women the fT4 level was within normal limits. Changes in given parameters were accompanied by increase in total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL CH) and very low-density lipoprotein cholesterol (VLDL CH) and decrease in high-density lipoprotein cholesterol (HDL CH) in patients with MS and chronic CAD regardless of gender, whereas only TG and VLDL CH were increased in patients with MS with obesity without chronic CAD. Interventricular septal thickness(IVST), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic size (LVEDS) as well as left atrium anteroposterior dimension (LA) increased in men and women with comorbid pathology, whereas only IVST and LA were increased in MS. Increased prolactin and TSH in women in contrast to men in MS with obesity have been established. High levels of TSH were recorded in the presence of combined pathology regardless of gender. Conclusion. Thus, diagnostic features of MS with obesity without chronic CAD are characterized by hormonal abnormalities in women, in contrast to men, whereas endocrine changes are not gender-specific in the presence of comorbid pathology.

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