Angioedema associated with Helicobacter pylori and type 2 diabetes

Abstract

Angioedema without wheals with duration of symptoms over six weeks is relatively rare. This applies especially for the chronic forms of angioedema associated with metabolic, infectious, malignant, and systemic connective tissue disease. Described in the literature cases are rare, especially when the etiology of isolated angioedema associated with Helicobacter pylori and type 2 diabetes. We report a case of a 66-year-old male patient with recurrent isolated angioedema without wheals, affecting the upper lip, with a disease duration of one year and no symptoms of respiratory and gastrointestinal tract. Laboratory, immunological and serological studies we found only elevated blood sugar and elevated Anti Helicobacter pylori IgG antibody. In patients with type 2 diabetes mellitus etiology of angioedema may be associated with Helicobacter pylori and poor metabolic control. To be an effective treatment, the etiology of such phenomena should be precisely clarified with the respective set of immunological and serological tests.