Frontiers in Pharmacology (Aug 2022)

Strategies to safely target widely expressed soluble adenylyl cyclase for contraception

  • Jacob Ferreira,
  • Lonny R. Levin,
  • Jochen Buck

DOI
https://doi.org/10.3389/fphar.2022.953903
Journal volume & issue
Vol. 13

Abstract

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In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate regulated soluble adenylyl cyclase (sAC; ADCY10). This review details why sAC is uniquely druggable and outlines ways to target sAC for novel forms of male and female contraception.

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