Circulating microRNAs -The potential biomarkers for early diagnosis of osteoarthritis

Abstract

Osteoarthritis (OA) is the most common form of arthritis and is one of the main causes of joint pain, impaired mobility and physical disability. Early diagnosis of OA is an important factor for effective treatment. However, current diagnostic methods are not sensitive enough to detect changes in the initial stages of the disease. Therefore, the identification of biomarker allows for detection of OA at the early stage and monitor disease progression. Current studies have focused on circulating microRNA (miRNA) molecules due to many advantages: not digest by RNase, withstand harsh conditions (boiling, very low or high pH), store for long time, repeat freeze-thaw cycles and take samples with non-invasive methods. Many studies showed the potential of using circulating miRNA in the early diagnosis of OA in clinical practice. Thus, we proceed to review the research data of circulating miRNA in OA, as a theoretical basis for later experimental studies in Vietnam.

Keywords

• chẩn đoán sớm
• dấu chứng sinh học
• microrna tuần hoàn
• thoái hóa khớp