Nature Communications (Jul 2020)

Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling

  • Federico N. Soria,
  • Chiara Paviolo,
  • Evelyne Doudnikoff,
  • Marie-Laure Arotcarena,
  • Antony Lee,
  • Noémie Danné,
  • Amit Kumar Mandal,
  • Philippe Gosset,
  • Benjamin Dehay,
  • Laurent Groc,
  • Laurent Cognet,
  • Erwan Bezard

DOI
https://doi.org/10.1038/s41467-020-17328-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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The nanoscale organisation of the brain extracellular space can be studied in vivo. Here, the authors investigate how it changes in response to α-synuclein pathology, and identify interactions between microglia and the extracellular matrix.