Neurobiology of Disease (Feb 1995)
Detection of expanded CAG repeats in Bipolar Affective Disorder using the repeat expansion detection (RED) method
- Kerstin Lindblad,
- Per-Olof Nylander,
- An De bruyn,
- Daniel Sourey,
- Cecilia Zander,
- Christer Engström,
- Gösta Holmgren,
- Tom Hudson,
- Jayanti Chotai,
- Julien Mendlewicz,
- Christine Van Broeckhoven,
- Martin Schalling,
- Rolf Adolfsson
Affiliations
- Kerstin Lindblad
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Psychiatry, University of Umeå, Sweden; Neurogenetics Laboratory, Born Bunge Foundation, Department of Biochemistry, University of Antwerp (UIA), B2610-Antwerp, Belgium; Division of Psychiatry, Erasme Hospital, University of Brussels (ULB), Belgium; Whitehead Institute, Cambridge, MA, U.S.A.; Department of Clinical Genetics, University of Umeå, Sweden
- Per-Olof Nylander
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Psychiatry, University of Umeå, Sweden; Neurogenetics Laboratory, Born Bunge Foundation, Department of Biochemistry, University of Antwerp (UIA), B2610-Antwerp, Belgium; Division of Psychiatry, Erasme Hospital, University of Brussels (ULB), Belgium; Whitehead Institute, Cambridge, MA, U.S.A.; Department of Clinical Genetics, University of Umeå, Sweden
- An De bruyn
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Psychiatry, University of Umeå, Sweden; Neurogenetics Laboratory, Born Bunge Foundation, Department of Biochemistry, University of Antwerp (UIA), B2610-Antwerp, Belgium; Division of Psychiatry, Erasme Hospital, University of Brussels (ULB), Belgium; Whitehead Institute, Cambridge, MA, U.S.A.; Department of Clinical Genetics, University of Umeå, Sweden
- Daniel Sourey
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Psychiatry, University of Umeå, Sweden; Neurogenetics Laboratory, Born Bunge Foundation, Department of Biochemistry, University of Antwerp (UIA), B2610-Antwerp, Belgium; Division of Psychiatry, Erasme Hospital, University of Brussels (ULB), Belgium; Whitehead Institute, Cambridge, MA, U.S.A.; Department of Clinical Genetics, University of Umeå, Sweden
- Cecilia Zander
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Psychiatry, University of Umeå, Sweden; Neurogenetics Laboratory, Born Bunge Foundation, Department of Biochemistry, University of Antwerp (UIA), B2610-Antwerp, Belgium; Division of Psychiatry, Erasme Hospital, University of Brussels (ULB), Belgium; Whitehead Institute, Cambridge, MA, U.S.A.; Department of Clinical Genetics, University of Umeå, Sweden
- Christer Engström
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Psychiatry, University of Umeå, Sweden; Neurogenetics Laboratory, Born Bunge Foundation, Department of Biochemistry, University of Antwerp (UIA), B2610-Antwerp, Belgium; Division of Psychiatry, Erasme Hospital, University of Brussels (ULB), Belgium; Whitehead Institute, Cambridge, MA, U.S.A.; Department of Clinical Genetics, University of Umeå, Sweden
- Gösta Holmgren
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Psychiatry, University of Umeå, Sweden; Neurogenetics Laboratory, Born Bunge Foundation, Department of Biochemistry, University of Antwerp (UIA), B2610-Antwerp, Belgium; Division of Psychiatry, Erasme Hospital, University of Brussels (ULB), Belgium; Whitehead Institute, Cambridge, MA, U.S.A.; Department of Clinical Genetics, University of Umeå, Sweden
- Tom Hudson
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Psychiatry, University of Umeå, Sweden; Neurogenetics Laboratory, Born Bunge Foundation, Department of Biochemistry, University of Antwerp (UIA), B2610-Antwerp, Belgium; Division of Psychiatry, Erasme Hospital, University of Brussels (ULB), Belgium; Whitehead Institute, Cambridge, MA, U.S.A.; Department of Clinical Genetics, University of Umeå, Sweden
- Jayanti Chotai
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Psychiatry, University of Umeå, Sweden; Neurogenetics Laboratory, Born Bunge Foundation, Department of Biochemistry, University of Antwerp (UIA), B2610-Antwerp, Belgium; Division of Psychiatry, Erasme Hospital, University of Brussels (ULB), Belgium; Whitehead Institute, Cambridge, MA, U.S.A.; Department of Clinical Genetics, University of Umeå, Sweden
- Julien Mendlewicz
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Psychiatry, University of Umeå, Sweden; Neurogenetics Laboratory, Born Bunge Foundation, Department of Biochemistry, University of Antwerp (UIA), B2610-Antwerp, Belgium; Division of Psychiatry, Erasme Hospital, University of Brussels (ULB), Belgium; Whitehead Institute, Cambridge, MA, U.S.A.; Department of Clinical Genetics, University of Umeå, Sweden
- Christine Van Broeckhoven
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Psychiatry, University of Umeå, Sweden; Neurogenetics Laboratory, Born Bunge Foundation, Department of Biochemistry, University of Antwerp (UIA), B2610-Antwerp, Belgium; Division of Psychiatry, Erasme Hospital, University of Brussels (ULB), Belgium; Whitehead Institute, Cambridge, MA, U.S.A.; Department of Clinical Genetics, University of Umeå, Sweden
- Martin Schalling
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Psychiatry, University of Umeå, Sweden; Neurogenetics Laboratory, Born Bunge Foundation, Department of Biochemistry, University of Antwerp (UIA), B2610-Antwerp, Belgium; Division of Psychiatry, Erasme Hospital, University of Brussels (ULB), Belgium; Whitehead Institute, Cambridge, MA, U.S.A.; Department of Clinical Genetics, University of Umeå, Sweden
- Rolf Adolfsson
- Neurogenetics Unit, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden; Department of Psychiatry, University of Umeå, Sweden; Neurogenetics Laboratory, Born Bunge Foundation, Department of Biochemistry, University of Antwerp (UIA), B2610-Antwerp, Belgium; Division of Psychiatry, Erasme Hospital, University of Brussels (ULB), Belgium; Whitehead Institute, Cambridge, MA, U.S.A.; Department of Clinical Genetics, University of Umeå, Sweden
- Journal volume & issue
-
Vol. 2,
no. 1
pp. 55 – 62
Abstract
Genetic factors are of major aetiological importance in Bipolar Affective Disorder (BPAD type I and II). The exact mode of inheritance of BPAD is unknown, but the recent demonstration of anticipation suggests that dynamic mutations could be involved in the clinical expression of the disease.We have used the repeat expansion detection (RED) method to test whether the anticipation in BPAD could be explained by the presence of expanded trinucleotide repeat sequences. Using a (CTG)10oligonucleotide a significantly higher number of expanded CAG repeats were found in the genomic DNA of two independent samples of unrelated BPAD patients of Swedish and Belgian ancestry as compared with normal controls. The difference in repeat number was more consistent if data of the two samples of patients was pooled.In this study a CAG trinucleotide repeat expansion was associated for the first time with a major psychiatric disorder. It is possible that the CAG trinucleotide repeat expansion is involved in the clinical expression of BPAD and that it is the molecular basis explaining the phenomenon of anticipation observed in this disorder.
