Nature Communications (Aug 2020)
An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques
- Liqiang Feng,
- Qian Wang,
- Chao Shan,
- Chenchen Yang,
- Ying Feng,
- Jia Wu,
- Xiaolin Liu,
- Yiwu Zhou,
- Rendi Jiang,
- Peiyu Hu,
- Xinglong Liu,
- Fan Zhang,
- Pingchao Li,
- Xuefeng Niu,
- Yichu Liu,
- Xuehua Zheng,
- Jia Luo,
- Jing Sun,
- Yingying Gu,
- Bo Liu,
- Yongcun Xu,
- Chufang Li,
- Weiqi Pan,
- Jincun Zhao,
- Changwen Ke,
- Xinwen Chen,
- Tao Xu,
- Nanshan Zhong,
- Suhua Guan,
- Zhiming Yuan,
- Ling Chen
Affiliations
- Liqiang Feng
- Bioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Qian Wang
- Bioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Chao Shan
- State Key Laboratory of Virology, Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences
- Chenchen Yang
- Guangzhou nBiomed Ltd
- Ying Feng
- State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University
- Jia Wu
- State Key Laboratory of Virology, Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences
- Xiaolin Liu
- Guangzhou nBiomed Ltd
- Yiwu Zhou
- Department of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology
- Rendi Jiang
- State Key Laboratory of Virology, Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences
- Peiyu Hu
- Bioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Xinglong Liu
- Bioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Fan Zhang
- Bioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Pingchao Li
- Bioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Xuefeng Niu
- State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University
- Yichu Liu
- Bioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Xuehua Zheng
- Bioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Jia Luo
- Bioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Jing Sun
- State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University
- Yingying Gu
- State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University
- Bo Liu
- Guangzhou nBiomed Ltd
- Yongcun Xu
- Guangzhou nBiomed Ltd
- Chufang Li
- State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University
- Weiqi Pan
- State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University
- Jincun Zhao
- State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University
- Changwen Ke
- Guangdong Provincial Center for Disease Control and Prevention
- Xinwen Chen
- Bioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Tao Xu
- Bioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Nanshan Zhong
- State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University
- Suhua Guan
- Guangzhou nBiomed Ltd
- Zhiming Yuan
- State Key Laboratory of Virology, Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences
- Ling Chen
- Bioland Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-020-18077-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
A vaccine protecting from SARS-CoV-2 infection is needed. Here the authors generate a replication-incompetent adenovirus based vaccine expressing SARS-CoV-2 spike, show protection from infection in non-human primates, and analyze the immune response after intramuscular and intranasal vaccination.
