Nature Communications (Jan 2021)
Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma
- Jason Behary,
- Nadia Amorim,
- Xiao-Tao Jiang,
- Anita Raposo,
- Lan Gong,
- Emily McGovern,
- Ragy Ibrahim,
- Francis Chu,
- Carlie Stephens,
- Hazem Jebeili,
- Vincenzo Fragomeli,
- Yen Chin Koay,
- Miriam Jackson,
- John O’Sullivan,
- Martin Weltman,
- Geoffrey McCaughan,
- Emad El-Omar,
- Amany Zekry
Affiliations
- Jason Behary
- St George and Sutherland Clinical School, University of New South Wales
- Nadia Amorim
- St George and Sutherland Clinical School, University of New South Wales
- Xiao-Tao Jiang
- St George and Sutherland Clinical School, University of New South Wales
- Anita Raposo
- St George and Sutherland Clinical School, University of New South Wales
- Lan Gong
- St George and Sutherland Clinical School, University of New South Wales
- Emily McGovern
- St George and Sutherland Clinical School, University of New South Wales
- Ragy Ibrahim
- Department of Gastroenterology and Hepatology, St George Hospital
- Francis Chu
- Department of Surgery, St George Hospital
- Carlie Stephens
- Department of Gastroenterology and Hepatology, St George Hospital
- Hazem Jebeili
- Department of Gastroenterology and Hepatology, St George Hospital
- Vincenzo Fragomeli
- Department of Gastroenterology and Hepatology, Nepean Hospital
- Yen Chin Koay
- Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney
- Miriam Jackson
- St George and Sutherland Clinical School, University of New South Wales
- John O’Sullivan
- Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney
- Martin Weltman
- Department of Gastroenterology and Hepatology, Nepean Hospital
- Geoffrey McCaughan
- Liver Injury and Cancer, Centenary Institute, Royal Prince Alfred Hospital
- Emad El-Omar
- St George and Sutherland Clinical School, University of New South Wales
- Amany Zekry
- St George and Sutherland Clinical School, University of New South Wales
- DOI
- https://doi.org/10.1038/s41467-020-20422-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Disease-specific gut microbiome signatures have been previously defined for patients with liver cirrhosis or hepatocellular carcinoma (HCC). Here the authors examine the composition of the gut microbiota in cirrhotic patients with non-alcoholic fatty liver disease with or without HCC and evaluate how dysbiosis influences peripheral immune responses.
