Nature Communications (Dec 2017)
Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions
- C. T. Watson,
- A. T. Cohain,
- R. S. Griffin,
- Y. Chun,
- A. Grishin,
- H. Hacyznska,
- G. E. Hoffman,
- N. D. Beckmann,
- H. Shah,
- P. Dawson,
- A. Henning,
- R. Wood,
- A. W. Burks,
- S. M. Jones,
- D. Y. M. Leung,
- S. Sicherer,
- H. A. Sampson,
- A. J. Sharp,
- E. E. Schadt,
- S. Bunyavanich
Affiliations
- C. T. Watson
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- A. T. Cohain
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- R. S. Griffin
- Department of Anesthesia, Hospital for Special Surgery
- Y. Chun
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- A. Grishin
- Department of Pediatrics, Icahn School of Medicine at Mount Sinai
- H. Hacyznska
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- G. E. Hoffman
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- N. D. Beckmann
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- H. Shah
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- P. Dawson
- eEmmes Corporation
- A. Henning
- eEmmes Corporation
- R. Wood
- Department of Pediatrics, Johns Hopkins University
- A. W. Burks
- Department of Pediatrics, University of North Carolina
- S. M. Jones
- Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital
- D. Y. M. Leung
- Department of Pediatrics, National Jewish Health
- S. Sicherer
- Department of Pediatrics, Icahn School of Medicine at Mount Sinai
- H. A. Sampson
- Department of Pediatrics, Icahn School of Medicine at Mount Sinai
- A. J. Sharp
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- E. E. Schadt
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- S. Bunyavanich
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-017-02188-7
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Rising rates of peanut allergy pose a public health problem. Here, the authors profile blood transcriptomes during double-blind, placebo-controlled oral challenge in peanut-allergic children to identify gene and cell composition changes, and construct causal networks to detect key allergic reaction drivers.
