Peran Gen p53 dan Regulasi Apoptosis Pada Perkembangan Kanker, Khususnya Karsinoma Kepala dan Leher

Abstract

It is now well established that cancer is a complex genetic disease. These genetic alterations include the function of tumor supressor gene p 53 and apoptosis. The interaction between these factors have key role in cell proliferation and cell death. Functional lost of apoptotic regulation is an important thing in tumor pathogenesis as tumor will develop in rapid manner and indefinitely.