Association of Monocyte to High-Density Lipoprotein Cholesterol Ratio with Diabetic Retinopathy in Patients with Type II Diabetes Mellitus

Abstract

INTRODUCTION: The purpose of the study was to evaluate the association of monocyte to high-density lipoprotein cholesterol ratio (MHR) with diabetic retinopathy (DR) in patients with type II diabetes mellitus (DM). METHODS: Forty-five DM patients with DR included in the study. Similarly, 45 DM patients without DR and 45 healthy subjects were determined as control groups. The data were composed based on a retrospective scan of the medical records and laboratory archives of patients. RESULTS: The mean MHR was significantly higher in DR patients compared to DM patients without DR and healthy subjects. There was also a statistical difference between DM patients without DR and healthy subjects. The optimal cutoff value of MHR for DR was 9.17 with 82.9% sensitivity and 59.8% specificity and an area under the receiver operating characteristics curve was 0.755. DISCUSSION AND CONCLUSION: The MHR recognized as a potential biomarker of inflammation was significantly higher in patients with DR compared to the DM patients without DR and healthy subjects. Our results demonstrated that the MHR has high sensitivity and low specificity for DR.

Keywords

• diabetes mellitus
• diabetic retinopathy
• inflammation
• monocyte-to-hdl ratio
• sensitivity.