Frontiers in Aging Neuroscience (Sep 2022)
The role of brain derived neurotrophic factor in central nervous system
- Yiyi Li,
- Yiyi Li,
- Fang Li,
- Fang Li,
- Dongdong Qin,
- Dongdong Qin,
- Hongyu Chen,
- Hongyu Chen,
- Jianhao Wang,
- Jianhao Wang,
- Jiabei Wang,
- Jiabei Wang,
- Shafei Song,
- Shafei Song,
- Chao Wang,
- Chao Wang,
- Yamei Wang,
- Yamei Wang,
- Songyan Liu,
- Songyan Liu,
- Dandan Gao,
- Dandan Gao,
- Zhi-Hao Wang,
- Zhi-Hao Wang
Affiliations
- Yiyi Li
- Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
- Yiyi Li
- Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, China
- Fang Li
- Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
- Fang Li
- Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, China
- Dongdong Qin
- Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
- Dongdong Qin
- Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, China
- Hongyu Chen
- Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
- Hongyu Chen
- Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, China
- Jianhao Wang
- Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
- Jianhao Wang
- Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, China
- Jiabei Wang
- Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
- Jiabei Wang
- Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, China
- Shafei Song
- Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
- Shafei Song
- Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, China
- Chao Wang
- Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
- Chao Wang
- Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, China
- Yamei Wang
- Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
- Yamei Wang
- Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, China
- Songyan Liu
- Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
- Songyan Liu
- Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, China
- Dandan Gao
- Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
- Dandan Gao
- Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, China
- Zhi-Hao Wang
- Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China
- Zhi-Hao Wang
- Center for Neurodegenerative Disease Research, Renmin Hospital of Wuhan University, Wuhan, China
- DOI
- https://doi.org/10.3389/fnagi.2022.986443
- Journal volume & issue
-
Vol. 14
Abstract
Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor and the p75 neurotrophin receptor, involving in physiological and pathological processes throughout life. The diverse presence and activity of BDNF indicate its potential role in the pathogenesis, progression and treatment of both neurological and psychiatric disorders. This review is to provide a comprehensive assessment of the current knowledge and future directions in BDNF-associated research in the central nervous system (CNS), with an emphasis on the physiological and pathological functions of BDNF as well as its potential treatment effects in CNS diseases, including depression, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and cerebral ischemic stroke.
Keywords
