Interpretation of pharmacokinetic data in preclinical studies of new drugs. Single intravenous administration

Abstract

Review. Further development of the methodological level of the decision support system proposed for the organization of primary selection and experimental preclinical study of new drugs. Methods for describing and interpreting the main pharmacokinetic experiment (single intravenous administration of drugs) data are systematized. A scheme for choosing pharmacokinetic models based on visual pattern recognition is proposed. Visual data patterns allow prediction of pharmacokinetic behavior and properties of new drugs.

Keywords

• decision support system
• methodology
• pharmacokinetics
• models
• pattern recognition
• data analysis