Nature Communications (May 2019)
SORLA regulates endosomal trafficking and oncogenic fitness of HER2
- Mika Pietilä,
- Pranshu Sahgal,
- Emilia Peuhu,
- Niklas Z. Jäntti,
- Ilkka Paatero,
- Elisa Närvä,
- Hussein Al-Akhrass,
- Johanna Lilja,
- Maria Georgiadou,
- Olav M. Andersen,
- Artur Padzik,
- Harri Sihto,
- Heikki Joensuu,
- Matias Blomqvist,
- Irena Saarinen,
- Peter J. Boström,
- Pekka Taimen,
- Johanna Ivaska
Affiliations
- Mika Pietilä
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Pranshu Sahgal
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Emilia Peuhu
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Niklas Z. Jäntti
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Ilkka Paatero
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Elisa Närvä
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Hussein Al-Akhrass
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Johanna Lilja
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Maria Georgiadou
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Olav M. Andersen
- Danish Research Institute of Translational Neuroscience Nordic-EMBL Partnership (DANDRITE), Department of Biomedicine, Aarhus University
- Artur Padzik
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- Harri Sihto
- Laboratory of Molecular Oncology, Translational Cancer Biology Program, University of Helsinki and Comprehensive Cancer Center, Helsinki University Hospital
- Heikki Joensuu
- Laboratory of Molecular Oncology, Translational Cancer Biology Program, University of Helsinki and Comprehensive Cancer Center, Helsinki University Hospital
- Matias Blomqvist
- Institute of Biomedicine, University of Turku and Department of Pathology, Turku University Hospital
- Irena Saarinen
- Institute of Biomedicine, University of Turku and Department of Pathology, Turku University Hospital
- Peter J. Boström
- Department of Urology, University of Turku and Turku University Hospital
- Pekka Taimen
- Institute of Biomedicine, University of Turku and Department of Pathology, Turku University Hospital
- Johanna Ivaska
- Turku Bioscience Centre, University of Turku and Åbo Akademi University
- DOI
- https://doi.org/10.1038/s41467-019-10275-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
The EGF receptor HER2 is an oncogene protein thought to reside at the plasma membrane, but its endosomal trafficking is currently unclear. Here, the authors report that HER2 is endocytosed and that sortillin-related receptor 1 (SORLA) promotes endosomal HER2 recycling and HER2 oncogenic signalling.
