ClinicoEconomics and Outcomes Research (Jun 2021)
US Budget Impact Model for Selinexor, Bortezomib, and Dexamethasone for the Treatment of Previously Treated Multiple Myeloma
Abstract
Mike Dolph, 1 Gabriel Tremblay, 1 Hoyee Leong 2 1Health Economics Department, Purple Squirrel Economics, New York, NY, 10010, USA; 2Health Economics and Outcomes Research, Global Medical and Scientific Affairs, Karyopharm Therapeutics, Newton, MA, 02459, USACorrespondence: Hoyee Leong Email [email protected]: To estimate the budget impact of selinexor, bortezomib, and dexamethasone (XVd) in patients with previously treated multiple myeloma (MM) from the perspective of a private third-party payer and Medicare in the US.Methods: The introduction of XVd as an option for patients with previously treated MM compared to no introduction of XVd was considered from a private third-party US payer (with 1,000,000 members) and a Medicare perspective in one-year increments for 3 years. Total annual treatment costs were calculated as the sum of drug costs, costs of treating serious treatment emergent adverse events (grade ≥ 3), ongoing best supportive care costs, and mortality costs.Results: The absolute budget impact (Millions, USD) of including XVd from a private third-party payer plan perspective was
