Synthesis and antibacterial activity of novel N-acylsulfonamides

Malika Berredjem; Fouzia Bouchareb; Samira Ait Kaki; Maazouz Dekhil; Nour-Eddine Aouf

doi:10.1016/j.arabjc.2013.01.016

Arabian Journal of Chemistry (Feb 2017)

Synthesis and antibacterial activity of novel N-acylsulfonamides

Malika Berredjem,
Fouzia Bouchareb,
Samira Ait Kaki,
Maazouz Dekhil,
Nour-Eddine Aouf

Affiliations

Malika Berredjem: LCOA, Bioorganic Chemistry Group, Sciences Faculty, Chemistry Department Badji-Mokhtar, Annaba University, BP 12, 23000, Algeria
Fouzia Bouchareb: LCOA, Bioorganic Chemistry Group, Sciences Faculty, Chemistry Department Badji-Mokhtar, Annaba University, BP 12, 23000, Algeria
Samira Ait Kaki: LCOA, Bioorganic Chemistry Group, Sciences Faculty, Chemistry Department Badji-Mokhtar, Annaba University, BP 12, 23000, Algeria
Maazouz Dekhil: Central Laboratory CHU Dorban – Annaba, Algeria
Nour-Eddine Aouf: LCOA, Bioorganic Chemistry Group, Sciences Faculty, Chemistry Department Badji-Mokhtar, Annaba University, BP 12, 23000, Algeria

DOI: https://doi.org/10.1016/j.arabjc.2013.01.016
Journal volume & issue: Vol. 10, no. S1
pp. S1095 – S1099

Abstract

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A series of novel N-acylsulfonamide derivatives were synthesized and characterized by 1H NMR, 13C NMR and HRMS. The N-acylsulfonamides were prepared in four steps (carbamoylation, sulfamoylation, deprotection and acylation) starting from chlorosulfonyl isocyanate. These compounds were evaluated in vitro as antimicrobial agents against representative strains of Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Acinetobacter, Klebsiella pneumonia and Pseudomonas aeruginosa).

Published in Arabian Journal of Chemistry

ISSN: 1878-5352 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Chemistry
Website: http://www.journals.elsevier.com/arabian-journal-of-chemistry/

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