THE PROBLEMS OF THE PATHOGENESIS AND TREATMENT OF ALCOHOLIC POLYNEUROPATHY

Abstract

The pathogenetic, clinical, diagnostic, and therapeutic aspects of alcoholic polyneuropathies, the most common nervous system complication in alcoholism, are considered. Two possible pathogenetic mechanisms of polyneuropathy: the direct toxic effect of ethanol and its metabolites and malnutrition with deficiency of B-group vitamins, including thiamine, are discussed. The use of B-group vitamins and α-lipoic acid preparations is recommended as pathogenetic therapy. The adjuvant analgesics - anticonvulsants and antidepressants are used to treat neuropathic pain.

Keywords

• alcoholism
• alcoholic polyneuropathy
• pathogenesis
• diagnosis
• treatment
• vitamins group b
• milgamma
• milgamma compositum
• thioctic acid
• thiogamma