Nutrients (Oct 2022)
Flavonoid Intake in Relation to Colorectal Cancer Risk and Blood Bacterial DNA
- Michela Carola Speciani,
- Marcello Cintolo,
- Mirko Marino,
- Maya Oren,
- Federica Fiori,
- Giorgio Gargari,
- Patrizia Riso,
- Clorinda Ciafardini,
- Federica Mascaretti,
- Maria Parpinel,
- Aldo Airoldi,
- Marcello Vangeli,
- Pierfrancesco Leone,
- Paolo Cantù,
- Pagona Lagiou,
- Cristian Del Bo’,
- Maurizio Vecchi,
- Pietro Carnevali,
- Barbara Oreggia,
- Simone Guglielmetti,
- Rossella Bonzi,
- Giulia Bonato,
- Monica Ferraroni,
- Carlo La Vecchia,
- Roberto Penagini,
- Massimiliano Mutignani,
- Marta Rossi
Affiliations
- Michela Carola Speciani
- Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology “G.A. Maccacaro”, Università degli Studi di Milano, 20133 Milan, Italy
- Marcello Cintolo
- Digestive and Interventional Endoscopy Unit, Azienda Socio Sanitaria Territoriale (ASST) Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy
- Mirko Marino
- Department of Food, Environmental and Nutritional Sciences (DeFENS), Università Degli Studi di Milano, 20133 Milan, Italy
- Maya Oren
- Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology “G.A. Maccacaro”, Università degli Studi di Milano, 20133 Milan, Italy
- Federica Fiori
- Department of Medicine, University of Udine, 33100 Udine, Italy
- Giorgio Gargari
- Department of Food, Environmental and Nutritional Sciences (DeFENS), Università Degli Studi di Milano, 20133 Milan, Italy
- Patrizia Riso
- Department of Food, Environmental and Nutritional Sciences (DeFENS), Università Degli Studi di Milano, 20133 Milan, Italy
- Clorinda Ciafardini
- Gastroenterology and Endoscopy Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
- Federica Mascaretti
- Gastroenterology and Endoscopy Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
- Maria Parpinel
- Department of Medicine, University of Udine, 33100 Udine, Italy
- Aldo Airoldi
- Hepatology and Gastroenterology Unit, Azienda Socio Sanitaria Territoriale (ASST) Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy
- Marcello Vangeli
- Hepatology and Gastroenterology Unit, Azienda Socio Sanitaria Territoriale (ASST) Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy
- Pierfrancesco Leone
- General Surgery Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
- Paolo Cantù
- Gastroenterology and Digestive Endoscopy Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori, 20133 Milan, Italy
- Pagona Lagiou
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, GR-115 27 Athens, Greece
- Cristian Del Bo’
- Department of Food, Environmental and Nutritional Sciences (DeFENS), Università Degli Studi di Milano, 20133 Milan, Italy
- Maurizio Vecchi
- Gastroenterology and Endoscopy Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
- Pietro Carnevali
- Division of Minimally–Invasive Surgical Oncology, Niguarda Cancer Center, Azienda Socio Sanitaria Territoriale (ASST) Grande Ospedale Metropolitano Niguarda, 20133 Milan, Italy
- Barbara Oreggia
- General Surgery Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
- Simone Guglielmetti
- Department of Food, Environmental and Nutritional Sciences (DeFENS), Università Degli Studi di Milano, 20133 Milan, Italy
- Rossella Bonzi
- Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology “G.A. Maccacaro”, Università degli Studi di Milano, 20133 Milan, Italy
- Giulia Bonato
- Digestive and Interventional Endoscopy Unit, Azienda Socio Sanitaria Territoriale (ASST) Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy
- Monica Ferraroni
- Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology “G.A. Maccacaro”, Università degli Studi di Milano, 20133 Milan, Italy
- Carlo La Vecchia
- Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology “G.A. Maccacaro”, Università degli Studi di Milano, 20133 Milan, Italy
- Roberto Penagini
- Gastroenterology and Endoscopy Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
- Massimiliano Mutignani
- Digestive and Interventional Endoscopy Unit, Azienda Socio Sanitaria Territoriale (ASST) Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy
- Marta Rossi
- Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology “G.A. Maccacaro”, Università degli Studi di Milano, 20133 Milan, Italy
- DOI
- https://doi.org/10.3390/nu14214516
- Journal volume & issue
-
Vol. 14,
no. 21
p. 4516
Abstract
Flavonoids have been inversely associated to colorectal cancer (CRC) and are plausible intermediaries for the relation among gut microbiome, intestinal permeability and CRC. We analyzed the relation of flavonoid intake with CRC and blood bacterial DNA. We conducted a case–control study in Italy involving 100 incident CRC cases and 200 controls. A valid and reproducible food–frequency questionnaire was used to assess dietary habits and to estimate six flavonoid subclass intakes. We applied qPCR and 16S rRNA gene profiling to assess blood bacterial DNA. We used multiple logistic regression to derive odds ratios (ORs) of CRC and Mann–Whitney and chi-–square tests to evaluate abundance and prevalence of operational taxonomic units (OTUs) according to flavonoid intakes. Inverse associations with CRC were found for anthocyanidins (OR for the highest versus the lowest tertile = 0.24, 95% confidence interval, CI = 0.11–0.52) and flavanones (OR = 0.18, 95% CI = 0.08–0.42). We found different abundance and prevalence according to anthocyanidin and flavanone intake for OTUs referring to Oligoflexales order, Diplorickettsiaceae family, Staphylococcus, Brevundimonas, Pelomonas and Escherischia–Shigella genera, and Flavobacterium and Legionella species. The study provides evidence to a protective effect of dietary anthocyanidins and flavanones on CRC and suggests an influence of flavonoids on blood bacterial DNA, possibly through intestinal permeability changes.
Keywords
