Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α

Daniel Tarade; Jeffrey E. Lee; Michael Ohh

doi:10.1038/s41467-019-11149-1

Nature Communications (Jul 2019)

Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α

Daniel Tarade,
Jeffrey E. Lee,
Michael Ohh

Affiliations

Daniel Tarade: Department of Laboratory Medicine & Pathobiology, University of Toronto
Jeffrey E. Lee: Department of Laboratory Medicine & Pathobiology, University of Toronto
Michael Ohh: Department of Laboratory Medicine & Pathobiology, University of Toronto

DOI: https://doi.org/10.1038/s41467-019-11149-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Paralogs HIF1α and HIF2α are important modulators regulating cellular transcriptional profile following hypoxia. Here, the authors investigate evolutionary substitutions that fine tune the interaction between HIFα and their regulator VHL in the vertebrate and invertebrate lineages.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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