An updated review of Typhonium flagelliforme: phytochemical compound, pharmacological activities and the use of vitexin and isovitexin as flavonoid compound in cosmetics development

Abstract

Typhonium flagelliforme, a plant known for its medicinal properties, has numerous benefits in the treatment of certain diseases. This comprehensive research provides a detailed review of the phytochemical and pharmacological activities of this plant, with a specific focus on the utilization of its flavonoid compounds, namely vitexin and isovitexin, in the development of cosmetic formulas. The phytochemical compounds include flavonoid, coumaric acid, and other polyphenols compounds. These compounds exhibit a wide range of pharmacological activities, including antioxidant, anti-inflammatory, anti-cancer, reduced immunosuppressive effects by reducing lymphocyte proliferation, antibacterial, improved immune system activities, and cured gastric ulcers. Based on these pharmacological activities, this research summarizes the utilization of flavonoid compounds, vitexin, and isovitexin, in developing cosmetic preparations. Subsequently, isovitexin has been shown to possess anti-oxidant and anti-inflammatory, and it shares similar pharmacological effects with vitexin, likely due to its similar chemical structure. Considering the excellent antioxidant capacity of isovitexin, there is a favorable opportunity to utilize it in the creation of cosmetic formulations. Therefore, further research is needed to formulate topical preparations and cosmetics containing Typhonium flagelliforme extract.