Frontiers in Endocrinology (Nov 2022)
The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence
- Chuqing Wu,
- Chuqing Wu,
- Chuqing Wu,
- Tong Wu,
- Tong Wu,
- Tong Wu,
- Dan Chen,
- Dan Chen,
- Dan Chen,
- Simin Wei,
- Simin Wei,
- Simin Wei,
- Weicheng Tang,
- Weicheng Tang,
- Weicheng Tang,
- Liru Xue,
- Liru Xue,
- Liru Xue,
- Jiaqiang Xiong,
- Yibao Huang,
- Yibao Huang,
- Yibao Huang,
- Yican Guo,
- Yican Guo,
- Yican Guo,
- Ying Chen,
- Ying Chen,
- Ying Chen,
- Meng Wu,
- Meng Wu,
- Meng Wu,
- Shixuan Wang,
- Shixuan Wang,
- Shixuan Wang
Affiliations
- Chuqing Wu
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
- Chuqing Wu
- National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China
- Chuqing Wu
- Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China
- Tong Wu
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
- Tong Wu
- National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China
- Tong Wu
- Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China
- Dan Chen
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
- Dan Chen
- National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China
- Dan Chen
- Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China
- Simin Wei
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
- Simin Wei
- National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China
- Simin Wei
- Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China
- Weicheng Tang
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
- Weicheng Tang
- National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China
- Weicheng Tang
- Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China
- Liru Xue
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
- Liru Xue
- National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China
- Liru Xue
- Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China
- Jiaqiang Xiong
- Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
- Yibao Huang
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
- Yibao Huang
- National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China
- Yibao Huang
- Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China
- Yican Guo
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
- Yican Guo
- National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China
- Yican Guo
- Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China
- Ying Chen
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
- Ying Chen
- National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China
- Ying Chen
- Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China
- Meng Wu
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
- Meng Wu
- National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China
- Meng Wu
- Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China
- Shixuan Wang
- Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
- Shixuan Wang
- National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, Hubei, China
- Shixuan Wang
- Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan, Hubei, China
- DOI
- https://doi.org/10.3389/fendo.2022.1025018
- Journal volume & issue
-
Vol. 13
Abstract
Chemotherapy is often a cause of premature ovarian insufficiency and infertility since the ovarian follicles are extremely sensitive to the effects of chemotherapeutic agents. Different chemotherapeutic agents with varying mechanisms of action may damage ovarian function differently. Taxanes are widely used in clinical cancer treatment, but the specific reproductive toxicological information is still controversial. This review described the impact and duration of taxanes on ovarian function in women and analyzed the possible reasons for different conclusions. Furthermore, the toxicity of taxanes on ovarian function and its possible mechanisms were discussed. The potential protective strategies and agents against ovarian damage induced by taxanes are also reviewed.
Keywords
