Cancer Management and Research (Dec 2020)
The Outcome of Unscreened Population in Colorectal Cancer: The Impact of Sex and Other Determinants on Cancer Stage
Abstract
Mesnad Alyabsi,1,2 Fouad Sabatin,2– 4 Abdul Rahman Jazieh2– 4 1Population Health Research Section, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; 2King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 3Oncology Department, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia; 4King Abdullah International Medical Research Center, Riyadh, Saudi ArabiaCorrespondence: Mesnad Alyabsi Population Health Research SectionKing Abdullah International Medical Research Center, P.O. Box 3660, Mail Code 1515, Riyadh 11481, Saudi ArabiaTel +966(11)429-4444 extension no. 94334Fax +966(11) 429-4440Email [email protected]: In Saudi Arabia, there is no population-based colorectal cancer (CRC) screening, and more than two-thirds of patients are diagnosed with a late stage. We assessed the association between sex and distant metastasis CRC and hypothesize that females, younger age, non-married, and patients with colon cancer would present with metastatic tumors.Patients and Methods: The retrospective cohort study used data from the Ministry of National Guard Cancer Registry. Logistic regression was used to assess the association between sex and metastatic CRC adjusting for patient covariates. In a sensitivity analysis, the association between sex and late-stage CRC was evaluated.Results: A total of 1016 CRC patients met the eligibility criteria, with 37.59% of females and 30.26% of males diagnosed with metastatic CRC. After adjusting for marital status, grade, and morphology, females were 20% more likely than males to present with a metastatic tumor 1.20 (95% CI, 1.04– 1.38).Conclusion: Although the entire Saudi population would benefit from CRC screening, women may benefit the most from targeted screening.Keywords: colorectal cancer, registry, survival, Saudi Arabia
