Nature Communications (Oct 2018)

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity

  • Chia-Yu Chung,
  • Amit Berson,
  • Jason R. Kennerdell,
  • Ashley Sartoris,
  • Travis Unger,
  • Sílvia Porta,
  • Hyung-Jun Kim,
  • Edwin R. Smith,
  • Ali Shilatifard,
  • Vivianna Van Deerlin,
  • Virginia M.-Y. Lee,
  • Alice Chen-Plotkin,
  • Nancy M. Bonini

DOI
https://doi.org/10.1038/s41467-018-06543-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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TDP-43 is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTD-TDP). Here, the authors identify the transcriptional elongation factor Ell as a strong modifier of TDP-43-mediated neurodegeneration through the Ell transcriptional elongation complexes LEC and SEC.